Kindlin-3 in the immune system

Fagerholm, S. C., Lek, H. S. and Morrison, V. L. (2014) Kindlin-3 in the immune system. American Journal of Clinical and Experimental Immunology, 3(1), pp. 37-42. (PMID:24660120) (PMCID:PMC3960760)

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Abstract

Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morrison, Dr Vicky
Authors: Fagerholm, S. C., Lek, H. S., and Morrison, V. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:American Journal of Clinical and Experimental Immunology
Publisher:E-Century Publishing Corporation
ISSN:2164-7712
ISSN (Online):2164-7712
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in American Journal of Clinical and Experimental Immunology 3(1):37-42
Publisher Policy:Reproduced under a Creative Commons License

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