Bestatin induces specific changes in trypanosoma cruzi dipeptide pool

Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P. and Robello, C. (2015) Bestatin induces specific changes in trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy, 59(5), pp. 2921-2925. (doi:10.1128/AAC.05046-14) (PMID:25712359)

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Abstract

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Creek, Dr Darren and Barrett, Professor Michael
Authors: Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P., and Robello, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Antimicrobial Agents and Chemotherapy
Journal Abbr.:Antimicrob Agents Chemother
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596

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