MEG-measured auditory steady-state oscillations show high test-retest reliability: a sensor and source-space analysis

Tan, H.-R.M. , Gross, J. and Uhlhaas, P.J. (2015) MEG-measured auditory steady-state oscillations show high test-retest reliability: a sensor and source-space analysis. NeuroImage, 122, pp. 417-426. (doi:10.1016/j.neuroimage.2015.07.055) (PMID:6216274)

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Abstract

Stability of oscillatory signatures across magnetoencephalography (MEG) measurements is an important prerequisite for basic and clinical research that has been insufficiently addressed. Here, we evaluated the test–retest reliability of auditory steady-state responses (ASSRs) over two MEG sessions. The study required participants (N = 13) to detect the rare occurrence of pure tones interspersed within a stream of 5 Hz or 40 Hz amplitude-modulated (AM) tones. Intraclass correlations (ICC; Shrout and Fleiss, 1979) were derived to assess stability of spectral power changes and the inter-trial phase coherence (ITPC) of task-elicited neural responses. ASSRs source activity was estimated using eLORETA beamforming from bilateral auditory cortex. ASSRs to 40 Hz AM stimuli evoked stronger power modulation and phase-locking than 5 Hz stimulation. Overall, spectral power and ITPC values at both sensor- and source-level showed robust ICC values. Notably, ITPC measures yielded higher ICCs (~ 0.86–0.96) between sessions compared to the assessment of spectral power change (~ 0.61–0.82). Our data indicate that spectral modulations and phase consistency of ASSRs in MEG data are highly reproducible, providing support for MEG-measured oscillatory parameters in basic and clinical research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Tan, Dr Heng-Ru May and Gross, Professor Joachim
Authors: Tan, H.-R.M., Gross, J., and Uhlhaas, P.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Psychology
Journal Name:NeuroImage
Publisher:Elsevier
ISSN:1053-8119
ISSN (Online):1095-9572
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in NeuroImage 122:417-426
Publisher Policy:Reproduced under a Creative Commons License

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