Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi: 10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)
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Abstract
Ageing is associated with functional, structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension. Characteristic features of large and small arteries that occur with ageing and during the development of hypertension include endothelial dysfunction, vascular remodelling, inflammation, calcification and increased stiffness. Arterial changes in young hypertensive patients mimic those in old normotensive individuals. Hypertension accelerates and augments age-related vascular remodelling and dysfunction, and ageing may impact on the severity of vascular damage in hypertension, indicating close interactions between biological ageing and blood pressure elevation. Molecular and cellular mechanisms underlying vascular alterations in ageing and hypertension are common and include aberrant signal transduction, oxidative stress and activation of pro-inflammatory and pro-fibrotic transcription factors. Strategies to suppress age-associated vascular changes could ameliorate vascular damage associated with hypertension. An overview on the vascular biology of ageing and hypertension is presented and novel molecular mechanisms contributing to these processes are discussed. The complex interaction between biological ageing and blood pressure elevation on the vasculature is highlighted.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Harvey, Dr Adam and Montezano, Dr Augusto and Touyz, Professor Rhian |
| Authors: | Harvey, A., Montezano, A. C., and Touyz, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Molecular and Cellular Cardiology |
| Publisher: | Elsevier Ltd. |
| ISSN: | 0022-2828 |
| ISSN (Online): | 1095-8584 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Journal of Molecular and Cellular Cardiology 83:112-121 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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