Genomes and phenomes of a population of outbred rats and its progenitors

Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi:10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)

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Abstract

Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Dr Delyth and Huynh, Miss Ngan and McBride, Dr Martin and Dominiczak, Professor Anna and Beattie, Mrs Elisabeth
Authors: Baud, A., Guryev, V., Hummel, O., Johannesson, M., Hermsen, R., Stridh, P., Graham, D., McBride, M. W., Foroud, T., Calderari, S., Diez, M., Ockinger, J., Beyeen, A. D., Gillett, A., Abdelmagid, N., Guerreiro-Cacais, A. O., Jagodic, M., Tuncel, J., Norin, U., Beattie, E., Huynh, N., Miller, W. H., Koller, D. L., Alam, I., Falak, S., Osborne-Pellegrin, M., Martinez-Membrives, E., Canete, T., Blazquez, G., Vicens-Costa, E., Mont-Cardona, C., Diaz-Moran, S., Tobena, A., Zelenika, D., Saar, K., Patone, G., Bauerfeind, A., Bihoreau, M.-T., Heinig, M., Lee, Y.-A., Rintisch, C., Schulz, H., Wheeler, D. A., Worley, K. C., Muzny, D. M., Gibbs, R. A., Lathrop, M., Lansu, N., Toonen, P., Ruzius, F. P., de Bruijn, E., Hauser, H., Adams, D. J., Keane, T., Atanur, S. s., Aitman, T. J., Flicek, P., Malinauskas, T., Jones, E. Y., Ekman, D., Lopez-Aumatell, R., Dominiczak, A. F., Holmdahl, R., Olsson, T., Gauguier, D., Hubner, N., Fernandez-Teruel, A., Cuppen, E., Mott, R., and Flint, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Scientific Data
Publisher:Nature Publishing Group
ISSN (Online):2052-4463
Copyright Holders:Copyright © 2015 The Authors

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