Kruiswijk, F., Labuschagne, C. F. and Vousden, K. (2015) p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nature Reviews Molecular Cell Biology, 16(7), pp. 393-405. (doi: 10.1038/nrm4007) (PMID:26122615)
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Abstract
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates various metabolic pathways, helping to balance glycolysis and oxidative phosphorylation, limiting the production of reactive oxygen species, and contributing to the ability of cells to adapt to and survive mild metabolic stresses. Although these activities may be integrated into the tumour suppressive functions of p53, deregulation of some elements of the p53-induced response might also provide tumours with a survival advantage.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kruiswijk, Dr Flore and Labuschagne, Dr Christiaan Fred and Vousden, Karen |
| Authors: | Kruiswijk, F., Labuschagne, C. F., and Vousden, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Molecular Cell Biology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1471-0072 |
| ISSN (Online): | 1471-0080 |
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