Association between cognition and gene polymorphisms involved in thrombosis and haemostasis

Quinn, T. J. , Alghamdi, J., Padmanabhan, S. , Porteous, D. J., Smith, B. H., Hocking, L., Deary, I. J., Gallacher, J., Messow, M. and Stott, D. J. (2015) Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, 37(4), p. 80. (doi:10.1007/s11357-015-9820-y) (PMID:26228839) (PMCID:26228839)

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Abstract

An association between blood markers of thrombosis and haemostasis and cognitive decline has been described. These results may be confounded by lifestyle and environmental factors. We used a Mendelian Randomisation approach to describe association between thrombosis/haemostasis genotypes and cognition. We studied genetic variants (single nucleotide polymorphisms) of circulating markers of thrombosis and haemostasis. Our chosen blood factors and associated polymorphisms were: D-dimer [rs12029080], fibrinogen [rs1800789], plasminogen activator inhibitor [rs2227631], von Willebrand factor [rs1063857]). We described association with multi-domain cognitive test scores using data from the Scottish Family Health Study. Cognitive data were analysed for individual tests and combined to give a general cognitive factor. In 20,288 subjects we found no evidence of association between cognitive function (individual tests and combined scores) and any of the above-mentioned single nucleotide polymorphisms. Lower scores on cognitive measures were associated with:increasing age, socioeconomic deprivation, blood pressure, waist-hip ratio, smoking, and vascular comorbidity (all p<0.001). In a post-hoc sensitivity analysis restricted to those aged over 50 years there was still no signal of association. Our data add to our understanding of determinants of cognition but are not definitive, the variation in blood levels explained by SNPs was modest and our sample size may have been insufficient to detect a modest association.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Messow, Dr Martina and Padmanabhan, Professor Sandosh and Quinn, Dr Terry and Stott J, Professor David
Authors: Quinn, T. J., Alghamdi, J., Padmanabhan, S., Porteous, D. J., Smith, B. H., Hocking, L., Deary, I. J., Gallacher, J., Messow, M., and Stott, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Age
Publisher:Springer Netherlands
ISSN:0161-9152
ISSN (Online):1574-4647
Copyright Holders:© American Aging Association 2015
First Published:First published in Age 37(4): 80 2015
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
602241Association between cognition and gene polymorphisms involved in thrombosis and haemostasisTerence QuinnAcademy of Medical Sciences (AMS)AMS-SGCL6-QuinnRI CARDIOVASCULAR & MEDICAL SCIENCES