The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men

Gray, S.R. , Clifford, M., Lancaster, R., Leggate, M., Davies, M. and Nimmo, M.A. (2009) The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine, 47(2), pp. 98-102. (doi:10.1016/j.cyto.2009.05.011) (PMID:19527938)

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Abstract

The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1 h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P < 0.05) in IL-6 and a 1.2-fold increase (P < 0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P < 0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P < 0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gray, Dr Stuart
Authors: Gray, S.R., Clifford, M., Lancaster, R., Leggate, M., Davies, M., and Nimmo, M.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cytokine
Publisher:Elsevier
ISSN:1043-4666
ISSN (Online):1096-0023

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