Robinson, M., Gray, S.R. , Watson, M.S., Kennedy, G., Hill, A., Belch, J.J.F. and Nimmo, M.A. (2010) Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome. Scandinavian Journal of Medicine and Science in Sports, 20(2), pp. 282-290. (doi: 10.1111/j.1600-0838.2009.00895.x) (PMID:19422646)
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Abstract
The aim of the current study was to investigate the levels of interleukin-6 (IL-6), its soluble receptors (sIL-6R and sgp130) and F2-isoprostanes, at rest and during exercise, in patients with chronic fatigue syndrome (CFS). Six male CFS patients and six healthy controls performed an incremental exercise test to exhaustion and a submaximal exercise bout to exhaustion. Blood samples taken in the submaximal test at rest, immediately post-exercise and 24 h post-exercise were analyzed for IL-6, sIL-6R, sgp130 and F2-isoprostanes. A further 33 CFS and 33 healthy control participants gave a resting blood sample for IL-6 and sIL-6R measurement. During the incremental exercise test only power output at the lactate threshold was lower (P<0.05) in the CFS group. F2-isoprostanes were higher (P<0.05) in CFS patients at rest and this difference persisted immediately and 24 h post-exercise. The exercise study found no differences in IL-6, sIL-6R or sgp130 at any time point between groups. In the larger resting group, there were no differences in IL-6 and sIL-6R between CFS and control groups. This investigation has demonstrated that patients with CFS do not have altered plasma levels of IL-6, sIL-6R or sgp130 either at rest or following exercise. F2-isoprostanes, however, were consistently higher in CFS patients.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gray, Professor Stuart |
Authors: | Robinson, M., Gray, S.R., Watson, M.S., Kennedy, G., Hill, A., Belch, J.J.F., and Nimmo, M.A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Scandinavian Journal of Medicine and Science in Sports |
Publisher: | Wiley-Blackwell Publishing Ltd. |
ISSN: | 0905-7188 |
ISSN (Online): | 1600-0838 |
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