The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

Ghashut, R. A., McMillan, D. C. , Kinsella, J., Vasilaki, A. T. , Talwar, D. and Duncan, A. (2016) The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin. Clinical Nutrition, 35(2), pp. 381-387. (doi:10.1016/j.clnu.2015.02.010) (PMID:25753552)

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Abstract

Background & aim: The magnitude of systemic inflammatory response, as evidenced by C-reactive protein (CRP), is a major factor associated with lower zinc and selenium. They may also be influenced by their binding proteins, such as albumin. The aim of the present study was to examine the relationships between plasma zinc, selenium and the systemic inflammatory response in a large cohort of patients referred for nutritional screen and also to examine these relationships in patients with critical illness. Methods: Patients referred for nutritional assessment of zinc (n = 743) and selenium (n = 833) and 114 patients with critical illness were examined. Intra-assay imprecision was <10% for these analytes. Results: In the nutritional screen cohort, plasma zinc was significantly associated with CRP (rs = −0.404, p < 0.001) and albumin (rs = 0.588, p < 0.001). For each CRP category (≤10, 11–80, >80 mg/l) the zinc/albumin ratio x100 was similar (31, 33 and 32 respectively, p = 0.029). Plasma selenium was significantly associated with CRP (rs = −0.489, p < 0.001) and albumin (rs = 0.600, p < 0.001). With increasing CRP category (≤10, 11–80, >80 mg/l) the selenium/albumin ratio ×100 was lower (2.3, 2.1 and 1.8 respectively, p < 0.001). Similar relationships were also observed in the cohort of patients with critical illness. Conclusion: Plasma zinc was associated with both CRP and albumin. The impact of the systemic inflammatory response could be largely adjusted by albumin concentrations. Plasma selenium was associated with both CRP and albumin. The impact of the systemic inflammatory response on plasma selenium concentrations could not be reasonably adjusted by albumin concentrations.

Item Type:Articles
Keywords:C-reactive protein; Albumin; Zinc; Selenium
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kinsella, Professor John and McMillan, Professor Donald and Vasilaki, Dr Katerina
Authors: Ghashut, R. A., McMillan, D. C., Kinsella, J., Vasilaki, A. T., Talwar, D., and Duncan, A.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Clinical Nutrition
Publisher:Elsevier Ltd.
ISSN:0261-5614
ISSN (Online):1532-1983

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