Adams, P. D., Jasper, H. and Rudolph, K. L. (2015) Aging-induced stem cell mutations as drivers for disease and cancer. Cell Stem Cell, 16(6), pp. 601-612. (doi: 10.1016/j.stem.2015.05.002) (PMID:26046760) (PMCID:PMC4509784)
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Abstract
Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here we discuss possible explanations for age-associated increases in the initiation and/or progression of mutant stem/progenitor clones and highlight the roles of stem cell quiescence, replication-associated DNA damage, telomere shortening, epigenetic alterations, and metabolic challenges as determinants of stem cell mutations and clonal dominance in aging.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Adams, Professor Peter |
Authors: | Adams, P. D., Jasper, H., and Rudolph, K. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Cell Stem Cell |
Publisher: | Elsevier Inc. |
ISSN: | 1934-5909 |
ISSN (Online): | 1875-9777 |
Copyright Holders: | Copyright © 2015 Elsevier Inc |
First Published: | First published in Cell Stem Cell 16(6):601-612 |
Publisher Policy: | Reproduced under a Creative Commons License |
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