Cellular imaging in rheumatic diseases

Benson, R. A. , McInnes, I. B. , Brewer, J. M. and Garside, P. (2015) Cellular imaging in rheumatic diseases. Nature Reviews Rheumatology, 11(6), pp. 357-367. (doi:10.1038/nrrheum.2015.34) (PMID:25800215)

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Abstract

Developments in cellular imaging now enable the real-time visualization of the choreographed sequence of events that underlie the development of immune responses in vivo. The previously unappreciated dynamics and anatomical context of cellular interactions, revealed in these studies, can have profound consequences for the 'decision' by the immune system to induce immunological priming versus immunological tolerance. Importantly, dysregulation of this balance can result in autoimmune diseases such as rheumatoid arthritis (RA). By further developing our understanding of how, where and when cells interact during immune responses, we can further dissect these events to assess how cell interactions might be aberrant in autoimmunity. A better knowledge of the mechanisms involved in cellular interactions by means of cellular imaging can help the development and targeting of therapies to particular disease stages and tissues in patients with RA in efforts to restore immune homeostasis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Benson, Dr Robert and Garside, Professor Paul and Brewer, Professor James
Authors: Benson, R. A., McInnes, I. B., Brewer, J. M., and Garside, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Rheumatology
Publisher:Nature Publishing Group
ISSN:1759-4790
ISSN (Online):1759-4804

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