Lysosomal proteins in cell death and autophagy

Mrschtik, M. and Ryan, K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal, 282(10), pp. 1858-1870. (doi:10.1111/febs.13253) (PMID:25735653)

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Abstract

Nearly 60 years ago, lysosomes were first described in the laboratory of Christian de Duve, a discovery that significantly contributed to him being awarded a share of the 1974 Nobel Prize in Physiology or Medicine for elucidating ‘the structural and functional organization of the cell’. Initially thought of as a simple waste degradation facility of the cell, these organelles recently emerged as signalling centres with connections to major cellular processes. This review provides an overview of the many roles of lysosomal proteins in two of these processes: cell death and autophagy. We discuss both resident lysosomal proteins as well those that temporarily associate with lysosomes to influence autophagy and cell death pathways. Particular focus is given to studies in mammalian cells and in vivo systems.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Mrschtik, M., and Ryan, K. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:FEBS Journal
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:1742-464X
ISSN (Online):1742-4658

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