The human voice areas: spatial organisation and inter-individual variability in temporal and extra-temporal cortices

Pernet, C. R. et al. (2015) The human voice areas: spatial organisation and inter-individual variability in temporal and extra-temporal cortices. NeuroImage, 119, pp. 164-174. (doi:10.1016/j.neuroimage.2015.06.050) (PMID:26116964)

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Abstract

fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard ‘localizers’ available in the visual domain. Here we present an fMRI ‘voice localizer’ scan allowing rapid and reliable localization of the voice-sensitive ‘temporal voice areas’ (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than non-vocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or “voice patches” along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McAleer, Dr Philip and Belin, Professor Pascal and Pernet, Dr Cyril and Bestelmeyer, Dr Patricia and Charest, Mr Ian and Crabbe, Mrs Frances and Latinus, Dr Marianne
Authors: Pernet, C. R., McAleer, P., Latinus, M., Gorgolewski, K. J., Charest, I., Bestelmeyer, P. E.G., Watson, R. H., Fleming, D., Crabbe, F., Valdes-Sosa, M., and Belin, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Psychology
Journal Name:NeuroImage
Publisher:Elsevier B.V.
ISSN:1053-8119
ISSN (Online):1095-9572
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in NeuroImage 119:164-174
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
429751The perception of voice gender and identity - a combined behavioural, electrophysiological and neuroimaging approachPascal BelinBiotechnology and Biological Sciences Research Council (BBSRC)BB/E003958/1INP - CENTRE FOR COGNITIVE NEUROIMAGING
571171Cerebral processing of nonverbal affective vocalizationsPascal BelinBiotechnology and Biological Sciences Research Council (BBSRC)BB/J003654/1INP - CENTRE FOR COGNITIVE NEUROIMAGING
561961Audiovisual integration of identity information from the face and voice: a combined behavioural, fMRI and MEG studyPascal BelinBiotechnology and Biological Sciences Research Council (BBSRC)BB/I022287/1INP - CENTRE FOR COGNITIVE NEUROIMAGING