Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Nuesch, E. et al. (2016) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45(6), pp. 1927-1937. (doi:10.1093/ije/dyv074) (PMID:25979724)

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Abstract

Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D. Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P < 0.001), triglycerides (P < 0.001), non high-density (non-HDL) cholesterol (P < 0.001), C-reactive protein (P = 0.042), and systolic blood pressure (P = 0.064) and higher levels of forced expiratory volume in 1 s and forced vital capacity (P < 0.001 for both). Conclusions: Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna
Authors: Nuesch, E., Dale, C., Palmer, T.M., White, J., Keating, B.J., van Iperen, E.P., Goel, A., Padmanabhan, S., Asselbergs, F.W., Verschuren, W., Wijmenga, C., Van der Schouw, Y., Onland-Moret, N., Lange, L.A., Hovingh, G., Sivapalaratnam, S., Morris, R.W., Whincup, P.H., Wannamethe, G.S., Gaunt, T.R., Ebrahim, S., Steel, L., Nair, N., Reiner, A.P., Kooperberg, C., Wilson, J.F., Bolton, J.L., McLachlan, S., Price, J.F., Strachan, M.W., Robertson, C.M., Kleber, M.E., Delgado, G., Marz, W., Melander, O., Dominiczak, A.F., Farrall, M., Watkins, H., Leusink, M., Maitland-van der Zee, A.H., de Groot, M.C., Dudbridge, F., Hingorani, A., Ben-Shlomo, Y., Lawlor, D.A., Amuzu, A., Caufield, M., Cavadino, A., Cooper, J., Davies, T., Drenos, F., Engmann, J., Finan, C., Giambartolomei, C., Hardy, R., Humphries, S., Hypponen, E., Kivimaki, M., Kuh, D., Kumari, M., Ong, K., Plagnol, V., Power, C., Richards, M., Shah, S., Shah, T., Sofat, R., Talmud, P., Wareham, N., Warren, H., Whittaker, J., Wong, A., Zabaneh, D., Davey Smith, G., Wells, J.C., Leon, D.A., Holmes, M.V., and Casas, J.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Epidemiology
Publisher:Oxford University Press
ISSN:0300-5771
ISSN (Online):1464-3685
Published Online:15 May 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in International Journal of Epidemiology 45(6):1927-1937
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
501161Inflammation, glucocorticoids and microvascular disease in the aetiology of cognitive impairment in type 2 diabetesGordon LoweMedical Research Council (MRC)G0500877SCHOOL OF MEDICINE