Ward, R. J., Pediani, J. D. , Godin, A. G. and Milligan, G. (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)
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Abstract
Background: The quaternary organization of G protein-coupled receptors remains a subject of considerable debate. Results: The serotonin 5-HT2C receptor is a mixture of monomers, dimers, and higher-order oligomers. These become predominantly monomers upon antagonist treatment. Conclusion: SpIDA indicates that the 5-HT2C receptor exists as mixtures of forms that are regulated in an antagonist-dependent manner. Significance: SpIDA delivers new insights into receptor quaternary structure.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Pediani, Dr John and Ward, Dr Richard and Milligan, Professor Graeme |
Authors: | Ward, R. J., Pediani, J. D., Godin, A. G., and Milligan, G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Journal of Biological Chemistry |
Journal Abbr.: | J Biol Chem. |
Publisher: | American Society for Biochemistry and Molecular Biology, Inc. |
ISSN: | 0021-9258 |
ISSN (Online): | 1083-351X |
First Published: | First published in Journal of Biological Chemistry 290(20):12844-12857 |
Publisher Policy: | Reproduced under a Creative Commons License |
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