Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi: 10.1038/nn740)
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Abstract
Rats harboring the <i>agu</i> mutation have altered behavior1 and brain pathology1 resembling human Parkinsonian syndromes2; notably, they have a movement disorder and age-progressive dysfunction and death of neurons in the midbrain (substantia nigra pars compacta) that use dopamine as a neurotransmitter. We present evidence that this phenotype is due to a mutation in the rat protein <i>kinase Cγ</i> (in rat, Prkcg; in mouse, Prkcc; in human, PRKCG) gene, which generates a premature stop codon, drastically reducing the level of synthesis of the catalytic domain of the brain-specific protein kinase Cγ protein.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Payne, Professor Anthony and Shiels, Professor Paul and Gilmore, Dr Des and Sutcliffe, Dr Roger and Bennett, Mr Neil and Davies, Professor Roger |
| Authors: | Craig, N.J., Alonso, M.B.D., Hawker, K.L., Shiels, P., Glencorse, T.A., Campbell, J.M., Bennett, N.K., Canham, M., Donald, D., Gardiner, M., Gilmore, D.P., MacDonald, R.J., Maitland, K., McCallion, A.S., Russell, D., Payne, A.P., Sutcliffe, R.G., and Davies, R.W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Nature Neuroscience |
| ISSN: | 1097-6256 |
| ISSN (Online): | 1546-1726 |
| Published Online: | 15 October 2001 |
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