A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome

Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi:10.1038/nn740)

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Abstract

Rats harboring the <i>agu</i> mutation have altered behavior1 and brain pathology1 resembling human Parkinsonian syndromes2; notably, they have a movement disorder and age-progressive dysfunction and death of neurons in the midbrain (substantia nigra pars compacta) that use dopamine as a neurotransmitter. We present evidence that this phenotype is due to a mutation in the rat protein <i>kinase Cγ</i> (in rat, Prkcg; in mouse, Prkcc; in human, PRKCG) gene, which generates a premature stop codon, drastically reducing the level of synthesis of the catalytic domain of the brain-specific protein kinase Cγ protein.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Payne, Professor Anthony and Shiels, Professor Paul and Gilmore, Dr Desmond and Sutcliffe, Dr Roger and Bennett, Mr Neil and Davies, Professor Roger
Authors: Craig, N.J., Alonso, M.B.D., Hawker, K.L., Shiels, P., Glencorse, T.A., Campbell, J.M., Bennett, N.K., Canham, M., Donald, D., Gardiner, M., Gilmore, D.P., MacDonald, R.J., Maitland, K., McCallion, A.S., Russell, D., Payne, A.P., Sutcliffe, R.G., and Davies, R.W.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Nature Neuroscience
ISSN:1097-6256
ISSN (Online):1546-1726
Published Online:15 October 2001

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