Tracing the evolutionary origins of insect renal function

Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi:10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi:10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

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Abstract

Knowledge on neuropeptide receptor systems is integral to understanding animal physiology. Yet, obtaining general insight into neuropeptide signalling in a clade as biodiverse as the insects is problematic. Here we apply fluorescent analogues of three key insect neuropeptides to map renal tissue architecture across systematically chosen representatives of the major insect Orders, to provide an unprecedented overview of insect renal function and control. In endopterygote insects, such as Drosophila, two distinct transporting cell types receive separate neuropeptide signals, whereas in the ancestral exopterygotes, a single, general cell type mediates all signals. Intriguingly, the largest insect Order Coleoptera (beetles) has evolved a unique approach, in which only a small fraction of cells are targets for neuropeptide action. In addition to demonstrating a universal utility of this technology, our results reveal not only a generality of signalling by the evolutionarily ancient neuropeptide families but also a clear functional separation of the types of cells that mediate the signal.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cabrero, Mr Pablo and Dow, Professor Julian and Terhzaz, Dr Selim and Davies, Professor Shireen and Halberg, Dr Kenneth
Authors: Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A., and Dow, J. A.T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2015 Macmillan Publishers Limited
First Published:First published in Nature Communications 6:6800
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
626691Functional Genomics of the enigmatic stellate cell.Shireen DaviesBiotechnology and Biological Sciences Research Council (BBSRC)BB/L002647/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
538311Drosophila model of oxalate nephrolithiasisJulian DowNational Institute of Health (NIH-BETH)1R01DK092408-01RI MOLECULAR CELL & SYSTEMS BIOLOGY
538312Drosophila model of oxalate nephrolithiasisJulian DowNational Institute of Health (NIH-BETH)5R01DK092408-02RI MOLECULAR CELL & SYSTEMS BIOLOGY