Insights into cell ontogeny, age and acute myeloid leukaemia

Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K. (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi: 10.1016/j.exphem.2015.05.008) (PMID:26051919)

Abstract

Acute Myeloid Leukaemia (AML) is a heterogenous disease of haematopoietic stem and progenitor cells (HSCs/HSPCs). The pathogenesis of AML involves cytogenetic abnormalities, genetic mutations and epigenetic anomalies. Whilst it is widely accepted that the cellular biology, gene expression and epigenetic landscape of normal HSCs changes with age, little is known about the interplay between the age at which the cell becomes leukaemic and the resultant leukaemia. Despite its rarity, childhood AML is a leading cause of childhood cancer mortality. Treatment is in general extrapolated from adult AML on the assumption that adult and paediatric AML are similar biological entities. However, distinct biological processes and epigenetic modifications in paediatric and adult AML may mean that response to novel therapies may be different in children compared to adults with AML. A better understanding of the key pathways involved in transformation and how these differ between childhood and adult AML is an important step in identifying effective treatment. This review aims to highlight both the commonalities and differences between paediatric and adult AML disease biology with respect to age.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Chaudhury, Dr Shahzya and Keeshan, Dr Karen and Morison, Miss Jessica and Gibson, Professor Brenda
• Authors: Chaudhury, S. S., Morison, J. K., Gibson, B. E.S., and Keeshan, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Experimental Hematology
• Publisher: Elsevier B.V.
• ISSN: 0301-472X
• ISSN (Online): 1873-2399
• Copyright Holders: Copyright © 2015 Elsevier B.V.
• First Published: First published in Experimental Hematology 43(9):745-755
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.