Proteinuria and its relation to cardiovascular disease

Currie, G. and Delles, C. (2013) Proteinuria and its relation to cardiovascular disease. International Journal of Nephrology and Renovascular Disease, 7, pp. 13-24. (doi:10.2147/IJNRD.S40522) (PMID:24379690) (PMCID:PMC3873205)

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Abstract

Chronic kidney disease (CKD) and its associated morbidity pose a worldwide health problem. As well as risk of endstage renal disease requiring renal replacement therapy, cardiovascular disease is the leading cause of premature death among the CKD population. Proteinuria is a marker of renal injury that can often be detected earlier than any tangible decline in glomerular filtration rate. As well as being a risk marker for decline in renal function, proteinuria is now widely accepted as an independent risk factor for cardiovascular morbidity and mortality. This review will address the prognostic implications of proteinuria in the general population as well as other specific disease states including diabetes, hypertension and heart failure. A variety of pathophysiological mechanisms that may underlie the relationship between renal and cardiovascular disease have been proposed, including insulin resistance, inflammation, and endothelial dysfunction. As proteinuria has evolved into a therapeutic target for cardiovascular risk reduction in the clinical setting we will also review therapeutic strategies that should be considered for patients with persistent proteinuria.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Delles, Professor Christian and Currie, Dr Gemma
Authors: Currie, G., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Nephrology and Renovascular Disease
Publisher:Dove Press
ISSN:1178-7058
ISSN (Online):1178-7058
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in International Journal of Nephrology and Renovascular Disease 7:13-24
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
601881HOMAGE: Heart OMics in AGEingChristian DellesEuropean Commission (EC)305507RI CARDIOVASCULAR & MEDICAL SCIENCES