Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments

Berry, C. , Corcoran, D., Hennigan, B., Watkins, S., Layland, J. and Oldroyd, K. G. (2015) Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments. European Heart Journal, 36(45), pp. 3155-3164. (doi:10.1093/eurheartj/ehv206) (PMID:26038588) (PMCID:PMC4816759)

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Abstract

Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and improvements in the diagnosis and treatment of CAD can reduce the health and economic burden of this condition. Fractional flow reserve (FFR) is an evidence-based diagnostic test of the physiological significance of a coronary artery stenosis. Fractional flow reserve is a pressure-derived index of the maximal achievable myocardial blood flow in the presence of an epicardial coronary stenosis as a ratio to maximum achievable flow if that artery were normal. When compared with standard angiography-guided management, FFR disclosure is impactful on the decision for revascularization and clinical outcomes. In this article, we review recent developments with FFR in patients with stable CAD and recent myocardial infarction. Specifically, we review novel developments in our understanding of CAD pathophysiology, diagnostic applications, prognostic studies, clinical trials, and clinical guidelines.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Corcoran, Dr David and Hennigan, Dr Barry and Oldroyd, Dr Keith and Layland, Dr Jamie and Berry, Professor Colin
Authors: Berry, C., Corcoran, D., Hennigan, B., Watkins, S., Layland, J., and Oldroyd, K. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:European Heart Journal
Journal Abbr.:Eur. heart j.
Publisher:Oxford University Press
ISSN:0195-668X
ISSN (Online):1522-9645
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in European Heart Journal 36(45):3155-3164
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
692781A prospective comparison of the diagnostic utility of invasive coronary physiological indices and quantitative perfusion MRI in patients with coronary heart disease...Keith OldroydBritish Heart Foundation (BHF)PG/14/97/31263RI CARDIOVASCULAR & MEDICAL SCIENCES