Biodegradable microparticles for oral immunization

O'Hagan, D.T., McGee, J.P., Holmgren, J., Mowat, A. M., Donachie, A.M., Mills, K.H.G., Gaisford, W., Rahman, D. and Challacombe, S.J. (1993) Biodegradable microparticles for oral immunization. Vaccine, 11(2), pp. 149-154. (doi: 10.1016/0264-410X(93)90011-L) (PMID:843861)

Abstract

Ovalbumin (OVA) was entrapped in poly(lactide-co-glycolide) microparticles and administered to mice. Following intraperitoneal immunization, the microparticles induced both proliferative T-cell responses and cytotoxic T-cell responses in spleen cells. Following oral immunization, the mean salivary IgA antibody response to microparticles was significantly greater than the response to soluble OVA (p < 0.0001). Serum IgG antibody levels were also significantly greater in the group administered microparticles (p < 0.001). Cholera toxin B subunit was also entrapped in microparticles. Following oral immunization in mice, specific antibody-secreting cells were detected both in the spleens and in the mesenteric lymph nodes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mowat, Professor Allan and Donachie, Ms Anne Marie
• Authors: O'Hagan, D.T., McGee, J.P., Holmgren, J., Mowat, A. M., Donachie, A.M., Mills, K.H.G., Gaisford, W., Rahman, D., and Challacombe, S.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Vaccine
• Publisher: Elsevier
• ISSN: 0264-410X
• ISSN (Online): 1873-2518