Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies

Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M. and Touyz, R. M. (2015) Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Canadian Journal of Cardiology, 31(5), pp. 631-641. (doi:10.1016/j.cjca.2015.02.008) (PMID:25936489)

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Abstract

Hypertension is a major cardiovascular risk factor. Of the many processes involved in the pathophysiology of hypertension, vascular damage due to oxidative stress (excess bioavailability of reactive oxygen species [ROS]) is particularly important. Physiologically, ROS regulate vascular function through redox-sensitive signalling pathways. In hypertension, oxidative stress promotes endothelial dysfunction, vascular remodelling, and inflammation, leading to vascular damage. Vascular ROS are derived primarily by nicotinamide adenine dinucleotide phosphate oxidases, which are prime targets for therapeutic development. Although experimental evidence indicates a causative role for oxidative stress in hypertension, human data are less convincing. This might relate, in part, to suboptimal methods to accurately assess the redox state. Herein we review current knowledge on oxidative stress in vascular pathobiology and implications in human hypertension. We also discuss biomarkers to assess the redox state in the clinic, highlight novel strategies to inhibit ROS production, and summarize how lifestyle modifications promote vascular health by reducing oxidative stress.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harvey, Dr Adam and Tsiropoulou, Miss Sofia and Dulak-Lis, Ms Maria and Montezano, Dr Augusto and Touyz, Professor Rhian
Authors: Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Canadian Journal of Cardiology
Publisher:Elsevier Inc.
ISSN:0828-282X
ISSN (Online):1916-7075

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