Seshasai, S.R.K., Bennett, R.L., Petrie, J.R. , Bengus, M., Ekman, S., Dixon, M., Herz, M., Buse, J.B. and Ray, K.K. (2015) Cardiovascular safety of the glucagon-like peptide-1 receptor agonist taspoglutide in people with type 2 diabetes: an individual participant data meta-analysis of randomized controlled trials. Diabetes, Obesity and Metabolism, 17(5), pp. 505-510. (doi: 10.1111/dom.12448) (PMID:25656522)
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Abstract
Aims: To study the short-term cardiovascular effects of the once-weekly glucagon-like peptide-1 receptor agonist taspoglutide.<p></p> Methods: We conducted a meta-analysis of individual-participant data from nine randomized controlled trials in the T-Emerge programme, which assessed the efficacy and safety of taspoglutide in type 2 diabetes. Our primary outcome was a composite of death from cardiovascular disease (CVD) and acute myocardial infarction, stroke and hospitalization for unstable angina.<p></p> Results: Overall, 7056 individuals were included in the analysis, and there were 67 primary endpoint events during 7478 person-years of follow-up (40 vs 27 events in the intervention vs control groups, respectively). The odds ratio for the composite endpoint among people randomized to taspoglutide was 0.94 (95% confidence interval 0.57–1.56), which was robust across multiple subgroups. Longer-term data were not available as the development of taspoglutide was stopped because of gastrointestinal intolerance and serious hypersensitivity reactions.<p></p> Conclusions: The available data suggest that short-term, once-weekly administration of taspoglutide was not associated with an excess risk of CVD, and provide insights relevant to the development of other novel once-weekly incretin mimetics.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Petrie, Professor John |
| Authors: | Seshasai, S.R.K., Bennett, R.L., Petrie, J.R., Bengus, M., Ekman, S., Dixon, M., Herz, M., Buse, J.B., and Ray, K.K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Diabetes, Obesity and Metabolism |
| Publisher: | John Wiley & Sons Ltd. |
| ISSN: | 1462-8902 |
| ISSN (Online): | 1463-1326 |
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