Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease

Poortvliet, R. K.E. et al. (2015) Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease. American Journal of Hypertension, 28(4), pp. 469-479. (doi:10.1093/ajh/hpu181) (PMID:25298176)

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Abstract

BACKGROUND: Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons.<p></p> METHODS: Nested observational study within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) among 3,794 male and female participants (range 70–82 years) with a history of, or risk factors for cardiovascular disease. Individual visit-to-visit variability in systolic and diastolic blood pressure and pulse pressure (expressed as 1 SD in mm Hg) was assessed using nine measurements over 2 years. Correlates of higher visit-to-visit variability were examined at baseline, including markers of inflammation, endothelial function, renal function and glucose homeostasis.<p></p> RESULTS: Over the first 2 years, the mean intra-individual variability (1 SD) was 14.4mm Hg for systolic blood pressure, 7.7mm Hg for diastolic blood pressure, and 12.6mm Hg for pulse pressure. After multivariate adjustment a higher level of interleukin-6 at baseline was consistently associated with higher intra-individual variability of blood pressure, including systolic, diastolic, and pulse pressure. Markers of endothelial function (Von Willebrand factor, tissue plasminogen activator), renal function (glomerular filtration rate) and glucose homeostasis (blood glucose, homeostatic model assessment index) were not or to a minor extent associated with blood pressure variability.<p></p> CONCLUSION: In an elderly population at risk of cardiovascular disease, inflammation (as evidenced by higher levels of interleukin-6) is associated with higher intra-individual variability in systolic, diastolic, and pulse pressure.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Poortvliet, Dr Rosalinde and Stott, Professor David J and Sattar, Professor Naveed and Ford, Professor Ian and Lloyd, Miss Suzanne
Authors: Poortvliet, R. K.E., Lloyd, S. M., Ford, I., Sattar, N., de Craen, A. J.M., Wijsman, L. W., Mooijaart, S. P., Westendorp, R. G.J., Jukema, J. W., de Ruijter, W., Gussekloo, J., and Stott, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:American Journal of Hypertension
Publisher:Oxford University Press
ISSN:0895-7061
ISSN (Online):1941-7225

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