Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda

Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., Elliott, A., Whitby, D. and Newton, R. (2015) Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda. Tropical Medicine and International Health, 20(5), pp. 665-672. (doi:10.1111/tmi.12464) (PMID:25611008)

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Abstract

Objective: Unlike other herpes viruses, Kaposi's sarcoma-associated herpes virus (KSHV) is not ubiquitous worldwide and is most prevalent in sub-Saharan Africa. The reasons for this are unclear. As part of a wider investigation of factors that facilitate transmission in Uganda, a high prevalence country, we examined the association between antimalaria antibodies and seropositivity against KSHV.

Methods: Antibodies against P. falciparum merozoite surface protein (PfMSP)-1, P. falciparum apical membrane antigen (PfAMA)-1 and KSHV antigens (ORF73 and K8.1) were measured in samples from 1164 mothers and 1227 children.

Results: Kaposi's sarcoma-associated herpes virus seroprevalence was 69% among mothers and 15% children. Among mothers, KSHV seroprevalence increased with malaria antibody titres: from 60% to 82% and from 54% to 77%, comparing those with the lowest and highest titres for PfMSP-1 and PfAMA-1, respectively (P < 0.0001). Among children, only antibodies to PfAMA-1 were significantly associated with KSHV seropositivity, (P < 0.0001). In both mothers and children, anti-ORF73 antibodies were more strongly associated with malaria antibodies than anti-K8.1 antibodies.

Conclusion: The association between malaria exposure and KSHV seropositivity suggests that malaria is a cofactor for KSHV infection or reactivation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wakeham, Dr Katie
Authors: Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., Elliott, A., Whitby, D., and Newton, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Tropical Medicine and International Health
Publisher:John Wiley & Sons Ltd.
ISSN:1360-2276
ISSN (Online):1365-3156
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Tropical Medicine and International Health 20(6):665-672
Publisher Policy:Reproduced under a Creative Commons License

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