Galluzzi, L. et al. (2015) Autophagy in malignant transformation and cancer progression. EMBO Journal, 34(7), pp. 856-880. (doi: 10.15252/embj.201490784) (PMID:25712477) (PMCID:PMC4388596)
Full text not currently available from Enlighten.
Abstract
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ryan, Professor Kevin |
Authors: | Galluzzi, L., Pietrocola, F., Bravo-San Pedro, J.M., Amaravadi, R.K., Baehrecke, E.H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D.A., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, M.C., Martin, S.J., Penninger, J., Piacentini, M., Rubinsztein, D.C., Simon, H.-U., Simonsen, A., Thorburn, A.M., Velasco, G., Ryan, K.M., and Kroemer, G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | EMBO Journal |
Publisher: | Wiley |
ISSN: | 0261-4189 |
ISSN (Online): | 1460-2075 |
University Staff: Request a correction | Enlighten Editors: Update this record