Genetic and molecular aspects of hypertensin

Padmanabhan, S. , Caulfield, M. and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi:10.1161/CIRCRESAHA.116.303647) (PMID:25767282)

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Abstract

Until recently, significant advances in our understanding of the mechanisms of blood pressure regulation arose from studies of monogenic forms of hypertension and hypotension, which identified rare variants that primarily alter renal salt handling. Genome-wide association and exome sequencing studies over the past 6 years have resulted in an unparalleled burst of discovery in the genetics of blood pressure regulation and hypertension. More importantly, genome-wide association studies, while expanding the list of common genetic variants associated with blood pressure and hypertension, are also uncovering novel pathways of blood pressure regulation that augur a new era of novel drug development, repurposing, and stratification in the management of hypertension. In this review, we describe the current state of the art of the genetic and molecular basis of blood pressure and hypertension.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna
Authors: Padmanabhan, S., Caulfield, M., and Dominiczak, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Circulation Research
Publisher:Lippincott Williams & Wilkins
ISSN:0009-7330
ISSN (Online):1524-4571

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
570081Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.Sandosh PadmanabhanBritish Heart Foundation (BHF)PG/12/85/29925RI CARDIOVASCULAR & MEDICAL SCIENCES
174241United Kingdom Collaborative Study to Identify the Major Genes Responsible for Human Essential Hypertension (BRIGHT)John ConnellMedical Research Council (MRC)G9521010SCHOOL OF MEDICINE
348311The British genetics of hypertension study - application to enhance TDT and control recruitment for fine mapping genes for hypertensionAnna DominiczakBritish Heart Foundation (BHF)PG/02/128 MCPG1RI CARDIOVASCULAR & MEDICAL SCIENCES