Padmanabhan, S. , Caulfield, M. and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi: 10.1161/CIRCRESAHA.116.303647) (PMID:25767282)
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Abstract
Until recently, significant advances in our understanding of the mechanisms of blood pressure regulation arose from studies of monogenic forms of hypertension and hypotension, which identified rare variants that primarily alter renal salt handling. Genome-wide association and exome sequencing studies over the past 6 years have resulted in an unparalleled burst of discovery in the genetics of blood pressure regulation and hypertension. More importantly, genome-wide association studies, while expanding the list of common genetic variants associated with blood pressure and hypertension, are also uncovering novel pathways of blood pressure regulation that augur a new era of novel drug development, repurposing, and stratification in the management of hypertension. In this review, we describe the current state of the art of the genetic and molecular basis of blood pressure and hypertension.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna |
| Authors: | Padmanabhan, S., Caulfield, M., and Dominiczak, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Circulation Research |
| Publisher: | Lippincott Williams & Wilkins |
| ISSN: | 0009-7330 |
| ISSN (Online): | 1524-4571 |
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