Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma

Ma, Y., Faller, W., Sansom, O. , Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi:10.1097/CMR.0000000000000135) (PMID:25535872)

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Publisher's URL: http://dx.doi.org/10.1097/CMR.0000000000000135

Abstract

Levels of the actin bundling protein fascin correlate with invasion and metastasis and reveal prognostic value in many epithelial carcinomas. However, we know very little about the potential role of fascin in melanoma. The purpose of this study is to compare fascin expression in primary melanomas and melanoma metastasis. Fascin expression was examined through the immunohistochemistry of paraffin embedded tissue microarrays including 560 cores of primary tumour and metastasis. Fascin expression was significantly elevated in 48 metastases compared with 254 primary tumours (P =0.034). In 187 patients with primary melanomas, fascin was not correlated with survival (P= 0.067), whereas low fascin was significantly correlated with the presence of ulceration (P = 0.005). Our results indicate that fascin status does not correlate with progression in melanoma. Upregulated fascin expression was detected in melanoma metastases, but was not correlated to patient outcome.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura and Faller, Dr William and Ma, Dr Yafeng and Sansom, Professor Owen
Authors: Ma, Y., Faller, W., Sansom, O., Brown, E. R., Doig, T. N., Melton, D. W., and Machesky, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Melanoma Research
Publisher:Lippincott, Williams & Wilkins
ISSN:0960-8931
ISSN (Online):1473-5636

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