Physical characterization and biological studies of a (streptidine)(PtIICl4) compound

Aliaga-Alcalde, N., George, S. D., Alfaro-Fuentes, I., Cooper, G. J.T. , Barba-Behrens, N., Bernès, S. and Reedijk, J. (2009) Physical characterization and biological studies of a (streptidine)(PtIICl4) compound. Polyhedron, 28(16), pp. 3459-3466. (doi: 10.1016/j.poly.2009.07.022)

Abstract

The synthesis, characterization and biological properties of a novel platinum compound, (H2Std)PtCl4(H2O)x (1, where x = 1–4; H2Std stands for streptidine, the cationic sugar component of streptomycin), are reported in the solid state and in solution. Reaction of streptidine sulfate ((H2Std)SO4) with K2PtCl4, yields the sparingly soluble hydrated compound (H2Std)PtCl4. Structural information has been attained by a variety of spectroscopic techniques, as well as by using Pt L3- and Cl K-edge X-ray absorption spectroscopy (XAS). The analyses of the data were completed by performing extended X-ray structural characterization of the free ligand as streptidine sulfate, which was found crucial to interpret the nature and structural arrangement of complex 1.

In addition, this work also presents the biological activity of complex 1, i.e. cytotoxic assays, antimicrobial studies, DNA titration and fluorescence in vitro experiments. The studies presented in this paper contribute to our understanding of the synergy between platinum and pharmaceutically relevant compounds.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cooper, Dr Geoff
• Authors: Aliaga-Alcalde, N., George, S. D., Alfaro-Fuentes, I., Cooper, G. J.T., Barba-Behrens, N., Bernès, S., and Reedijk, J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Polyhedron
• Publisher: Elsevier Ltd.
• ISSN: 0277-5387