Sensing the difference: the influence of anisotropic cues on cell behavior

Ballester-Beltrán, J., Biggs, M., Dalby, M. , Salmeron-Sanchez, M. and Leal-Egana, A. (2015) Sensing the difference: the influence of anisotropic cues on cell behavior. Frontiers in Materials, 2, 39. (doi:10.3389/fmats.2015.00039)

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From tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical and biological cues commonly presented in gradients. In this article we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients in vitro. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g. ventral/dorsal anisotropy).

Item Type:Articles
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Leal-Egana, Dr Aldo
Authors: Ballester-Beltrán, J., Biggs, M., Dalby, M., Salmeron-Sanchez, M., and Leal-Egana, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Frontiers in Materials
ISSN (Online):2296-8016
Copyright Holders:Copyright © 2015 The AuthorsBallester-beltrán, Biggs, Dalby, Salmeron-sanchez and Leal-egaña
First Published:First published in Frontiers in Materials 39:2
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
653731Synergistic microenvironments for non-union bone defectsMatthew DalbyMedical Research Council (MRC)MR/L0022710/1RI MOLECULAR CELL & SYSTEMS BIOLOGY