Emergency presentation of node-negative colorectal cancer treated with curative surgery is associated with poorer short and longer-term survival

Oliphant, R., Mansouri, D. , Nicholson, G. A., McMillan, D. C. , Horgan, P. G. and Morrison, D. S. (2014) Emergency presentation of node-negative colorectal cancer treated with curative surgery is associated with poorer short and longer-term survival. International Journal of Colorectal Disease, 29(5), pp. 591-598. (doi:10.1007/s00384-014-1847-5) (PMID:24651957)

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Abstract

Purpose: The majority of patients with node-negative colorectal cancer have excellent 5-year survival prospects, but up to a third relapse. Strategies to identify patients at higher risk of adverse outcomes are desirable to enable optimal treatment and follow-up. The aim of this study was to examine postoperative mortality and longer-term survival by mode of presentation for patients with node-negative colorectal cancer undergoing surgery with curative intent.<p></p> Methods: Patients from 16 hospitals in the west of Scotland between 2001 and 2004 were identified from a prospectively maintained regional clinical audit database. Postoperative mortality and 5-year relative survival by mode of presentation were recorded.<p></p> Results: Of 1,877 patients with node-negative disease, 251 (13.4 %) presented as an emergency. Those presenting as an emergency were more likely to be older (P = 0.023), have colon rather than rectal cancer (P < 0.001), have pT4 stage disease (P < 0.001), have extramural vascular invasion (P = 0.001), and receive surgery under the care of a nonspecialist surgeon (P < 0.001) compared to those presenting electively. The postoperative mortality rate was 3.3 % after elective and 12.8 % after emergency presentation (P < 0.001). Five-year relative survival was 91.8 % after elective and 66.8 % after emergency presentation (P < 0.001). The adjusted relative excess risk ratio for 5-year relative survival after emergency relative to elective presentation was 2.59 (95 % CI 1.67–4.01; P < 0.001) and 1.90 (95 % CI 1.00–3.62; P = 0.049) after exclusion of postoperative deaths.<p></p> Conclusions: Emergency presentation of node-negative colorectal cancer treated with curative intent was independently associated with higher postoperative mortality and poorer 5-year relative survival compared to elective presentation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mansouri, Dr David and Horgan, Professor Paul and Morrison, Dr David and Nicholson, Mr Gary and McMillan, Professor Donald
Authors: Oliphant, R., Mansouri, D., Nicholson, G. A., McMillan, D. C., Horgan, P. G., and Morrison, D. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:International Journal of Colorectal Disease
Publisher:Springer Berlin Heidelberg
ISSN:0179-1958
ISSN (Online):1432-1262

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