Infant body composition and adipokine concentrations in relation to maternal gestational weight gain

Estampador, A. C., Pomeroy, J., Renstrom, F., Nelson, S. M. , Mogren, I., Persson, M., Sattar, N. , Domellof, M. and Franks, P. W. (2014) Infant body composition and adipokine concentrations in relation to maternal gestational weight gain. Diabetes Care, 37(5), pp. 1432-1438. (doi:10.2337/dc13-2265) (PMID:24623025) (PMCID:PMC3994936)

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Abstract

OBJECTIVE To investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.

RESEARCH DESIGN AND METHODS This was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations.

RESULTS Rate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = −0.60, P = 0.002 and r = −0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = −0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed.

CONCLUSIONS Timing of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant’s glucose and adipokine concentrations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott and Sattar, Professor Naveed
Authors: Estampador, A. C., Pomeroy, J., Renstrom, F., Nelson, S. M., Mogren, I., Persson, M., Sattar, N., Domellof, M., and Franks, P. W.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Diabetes Care
Publisher:American Diabetes Association
ISSN:0149-5992
ISSN (Online):1935-5548
Copyright Holders:Copyright ©2014 by the American Diabetes Association
First Published:First published in Diabetes Care 37(5):1432-1438
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
512251Improving Pregnancy Outcome in Obese Women - the UK Pregnancies: Better Eating and Activity Trial (UPBEAT)Scott NelsonScottish Executive Health Department (SEHHD-CSO)CZB/4/680MVLS MED - REPRODUCTIVE & MATERNAL MED