Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract

Morris, H.T. and Machesky, L.M. (2015) Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract. British Journal of Cancer, 112(4), pp. 613-620. (doi:10.1038/bjc.2014.658) (PMID:25611303) (PMCID:PMC4333498)

[img]
Preview
Text
104821.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

572kB

Abstract

The formation of epithelial tissues allows organisms to specialise and form tissues with diverse functions and compartmentalised environments. The tight controls on cell growth and migration required to maintain epithelia can present problems such as the development and spread of cancer when normal pathways are disrupted. By attaining a deeper understanding of how cell migration is suppressed to maintain the epithelial organisation and how it is reactivated when epithelial tissues become mesenchymal, new insights into both cancer and development can be gained. Here we discuss recent developments in our understanding of epithelial and mesenchymal regulation of the actin cytoskeleton in normal and cancerous tissue, with a focus on the pancreas and intestinal tract.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura and Morris, Dr Hayley
Authors: Morris, H.T., and Machesky, L.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:British Journal of Cancer
Publisher:Nature Publishing Group
ISSN:0007-0920
ISSN (Online):1532-1827
Copyright Holders:Copyright © 2015 Cancer Research UK
First Published:First published in British Journal of Cancer 112(4):613-620
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record