A prospective longitudinal study of growth and pubertal progress in adolescents with inflammatory bowel disease

Mason, A., Malik, S., McMillan, M., Mcneilly, J. D., Bishop, J., McGrogan, P., Russell, R. K. and Ahmed, S. F. (2015) A prospective longitudinal study of growth and pubertal progress in adolescents with inflammatory bowel disease. Hormone Research in Paediatrics, 83(1), pp. 45-54. (doi: 10.1159/000369457) (PMID:25531796)

Abstract

Background: Puberty and growth may be affected in inflammatory bowel disease (IBD) but the extent is unclear. Methods: We performed a prospective study over 12 months in 63 adolescents (Crohn's disease, CD, n = 45; ulcerative colitis/IBD unclassified, UC, n = 18) with a median age of 13.4 years (range 10-16.6). Assessment included anthropometry, biochemical markers of growth and puberty and an assessment of quality of life by IMPACT-III. Results: Compared to the normal population, boys with CD were shorter, with a median height SDS (HtSDS) of -0.13 (-2.52 to 1.58; p < 0.05). In addition, the study cohort had a lower median IGF-1 SDS of -0.29 (-4.53 to 2.96; p = 0.008) and a higher median IGFBP3 SDS of 0.45 (-3.15 to 2.55; p = 0.002). Over the study period, the median Ht velocity (HV) was 5 cm/year (0.2-8.7) and the change in HtSDS was 0.06 (-0.48 to 0.57). The median difference between the chronological and bone age was 0.3 years (-2.5 to 3.0) and pubertal examination was not delayed. In the whole group, the erythrocyte sedimentation rate (ESR) showed an inverse association with HV (r = -0.29; p = 0.025) and IGF-1:IGFBP3 (r = -0.34; p = 0.016). The score in the body image domain, IMPACT-III, was inversely associated with HtSDS (r = -0.31; p = 0.03). Conclusion: Despite no evidence of pubertal delay, adolescents with IBD display growth retardation which may be associated with raised ESR, adverse quality of life measures and an abnormality of IGF-1 bioavailability.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Russell, Dr Richard and McMillan, Mr Martin and Mcneilly, Dr Jane and Mason, Dr Avril and Ahmed, Professor Syed Faisal
• Authors: Mason, A., Malik, S., McMillan, M., Mcneilly, J. D., Bishop, J., McGrogan, P., Russell, R. K., and Ahmed, S. F.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Hormone Research in Paediatrics
• Publisher: Karger
• ISSN: 1663-2818
• ISSN (Online): 1663-2826