The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets

Franchini, G. R., Pórfido, J. L., Ibáñez Shimabukuro, M., Rey Burusco, M. F., Bélgamo, J. A., Smith, B. O., Kennedy, M. W. and Córsico, B. (2015) The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 93, pp. 31-36. (doi:10.1016/j.plefa.2014.08.003) (PMID:25282399)

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Abstract

In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Malcolm and Franchini, Dr Gisela and Smith, Dr Brian
Authors: Franchini, G. R., Pórfido, J. L., Ibáñez Shimabukuro, M., Rey Burusco, M. F., Bélgamo, J. A., Smith, B. O., Kennedy, M. W., and Córsico, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Publisher:Elsevier Ltd.
ISSN:0952-3278
ISSN (Online):1532-2823

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