In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase - A type II located in the centrosomal region

McCahill, A. et al. (2005) In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase - A type II located in the centrosomal region. Cellular Signalling, 17, pp. 1158-1173. (doi:10.1016/j.cellsig.2005.04.003)

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Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Houslay, Professor Miles
Authors: McCahill, A., McSorley, T., Huston, E., Hill, E., Lynch, M., Gall, I., Keryer, G., Lygren, B., Tasken, K., van Heeke, G., and Houslay, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Cellular Signalling

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
208361PDE4 cAMP phosphodiesterses: intracellular targeting, SH3 domain interaction and phosphorylation by stress kinasesMiles HouslayMedical Research Council (MRC)G8604010Institute of Neuroscience and Psychology
294081PDE4 Cyclic AMP phosphodiesterasesMiles HouslayMedical Research Council (MRC)G8604010Institute of Neuroscience and Psychology
30692Molecular interaction between receptor signal transduction systems involving guanine nucleotide regulatory proteinsMiles HouslayMedical Research Council (MRC)G8604010Institute of Neuroscience and Psychology
343641PDE4 cAMP phosphodiesterases - intracellular targeting, SH3 Domain Interaction & phosphorylation by stress kinasesMiles HouslayMedical Research Council (MRC)G8604010Institute of Neuroscience and Psychology
97371Programme Grant (PG 8604010) Supplementation (Equipment). Molecular interaction between receptor transduction systems involving guanine nuclMiles HouslayMedical Research Council (MRC)G8604010Institute of Neuroscience and Psychology