The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review

van Wyk, H.C. , Park, J. , Roxburgh, C. , Horgan, P. , Foulis, A. and McMillan, D. C. (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treatment Reviews, 41(2), pp. 151-159. (doi:10.1016/j.ctrv.2014.12.007) (PMID:25549950)

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Abstract

Tumour budding reflects a detachment of tumour cells at the invasive front of carcinomas and is presumed to be an early step in the metastatic process. Tumour budding has received some attention in colorectal cancer as it has been proposed as an additional prognostic factor in colorectal cancer that may stratify patients into risk categories.<p></p> The purpose of the review was to examine (1): The different methods of detection using either routine stains (H&E) or immunohistochemistry; (2): to compare studies that examined the different methods used to identify tumour budding; and (3) to examine the impact of tumour budding on survival in primary operable colorectal cancer. Results from the present review suggest that tumour budding can be considered a promising and strong prognostic factor in colorectal cancer. However, the implementation of the assessment of tumour budding in routine pathological work will depend on a selected, internationally accepted scoring system and validation against other established prognostic factors in patients with colorectal cancer.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Park, Mr James and Foulis, Dr Alan and Horgan, Professor Paul and Roxburgh, Dr Campbell and McMillan, Professor Donald and Van Wyk, Dr Hester
Authors: van Wyk, H.C., Park, J., Roxburgh, C., Horgan, P., Foulis, A., and McMillan, D. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Cancer Treatment Reviews
Publisher:Elsevier Ltd.
ISSN:0305-7372
ISSN (Online):1532-1967

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