Targeting cell migration in rheumatoid arthritis

Asquith, D. L., Bryce, S. A. and Nibbs, R. J.B. (2015) Targeting cell migration in rheumatoid arthritis. Current Opinion in Rheumatology, 27(2), pp. 204-211. (doi: 10.1097/BOR.0000000000000150) (PMID:25603038)

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Purpose of review: To provide an update of past failures, future prospects and key challenges facing the therapeutic targeting of chemokines and their receptors in rheumatoid arthritis.

  Recent findings: Clinical trials in rheumatoid arthritis have been undertaken with small molecule antagonists or neutralizing antibodies targeting CCR1, CCR5 and CXCL10. Some encouraging results have emerged. Laboratory and clinical research has identified CCL19, CXCL13 and CXCL12, and their receptors, as potential future targets. Developments in our appreciation of posttranslational chemokine modification highlight the complexity of chemokine networks operating in inflamed tissues, and the substantial gaps in existing knowledge.

  Summary: Despite previous disappointments, there are still reasons to be optimistic that drugs targeting chemokines and their receptors could be developed for the treatment of rheumatoid arthritis. However, a deeper understanding of the chemokine networks at work in inflamed joints is a necessary prerequisite.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bryce, Mr Steven and Asquith, Dr Darren and Nibbs, Professor Rob
Authors: Asquith, D. L., Bryce, S. A., and Nibbs, R. J.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Rheumatology
Publisher:Lippincott Williams & Wilkins, Ltd.
ISSN (Online):1531-6963
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