From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

Neužil, P., Campos, C.D.M., Wong, C.C., Soon, J.B.W., Reboud, J. and Manz, A. (2014) From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC). Lab on a Chip, 14(13), pp. 2168-2176. (doi:10.1039/c4lc00310a)

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Abstract

We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing system. We demonstrate different configurations to perform most detection schemes currently in use in LOC systems, including some of the most advanced such as nanowire-based biosensing, surface plasmon resonance sensing, electrochemical detection and real-time PCR. The complete system is controlled by a single chip and the collected information is stored in situ, with the option of transferring the data to an external display by using a USB interface. In addition to providing a framework for truly portable real-life developments of LOC systems, we envisage that this system will have a significant impact on education, especially since it can easily demonstrate the benefits of integrated microanalytical systems.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Reboud, Dr Julien
Authors: Neužil, P., Campos, C.D.M., Wong, C.C., Soon, J.B.W., Reboud, J., and Manz, A.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Lab on a Chip
Publisher:Royal Society of Chemistry
ISSN:1473-0197
ISSN (Online):1473-0189
Copyright Holders:Copyright © 2014 The Royal Society of Chemistry
First Published:First published in Lab on a Chip 14(13):2168-2176
Publisher Policy:Reproduced under a Creative Commons License
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