Clark, J. S. , Delion, L. and Farrugia, L. J. (2015) Synthesis of four diastereomers of sclerophytin f and structural reassignment of several sclerophytin natural products. Chemistry: A European Journal, 21(12), pp. 4772-4780. (doi: 10.1002/chem.201406051) (PMID:25663662)
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Abstract
Synthesis of the triol that has been proposed to be the marine natural product sclerophytin F has been completed along with the syntheses of three diastereomers. Comparison of the NMR spectroscopic data for all four compounds to the data reported for the natural product reveals that sclerophytin F is not the 3S diastereomer of sclerophytin A as proposed by Friedrich and Paquette. Re-analysis of the NMR spectroscopic data for known sclerophytin natural products and synthetic analogues leads to the conclusion that sclerophytins E and F are the same compound. This finding has allowed structural reassignment of several other cladiellin natural products.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen and Farrugia, Dr Louis and Delion, Miss Laetitia |
Authors: | Clark, J. S., Delion, L., and Farrugia, L. J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemistry: A European Journal |
Journal Abbr.: | Chem. Eur J. |
Publisher: | Wiley-VCH Verlag |
ISSN: | 0947-6539 |
ISSN (Online): | 1521-3765 |
Copyright Holders: | Copyright © 2015 Wiley-VCH Verlag |
First Published: | First published in Chemistry: A European Journal 21(12):4772-4780 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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