Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas

Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S. and Jarrett, R. F. (2015) Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas. Journal of General Virology, 96, pp. 1863-1872. (doi:10.1099/vir.0.000106) (PMID:25722346)

Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S. and Jarrett, R. F. (2015) Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas. Journal of General Virology, 96, pp. 1863-1872. (doi:10.1099/vir.0.000106) (PMID:25722346)

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Abstract

Lymphoma is the most common haematopoietic malignancy in dogs but little is known about the aetiology of this heterogeneous group of cancers. In humans, the Epstein-Barr virus (EBV) is associated with several lymphoma subtypes. Recently, it has been suggested that EBV or an EBV-like virus is circulating in dogs. We therefore investigated whether EBV, or a novel herpesvirus, is associated with canine lymphoma using both serological and molecular techniques. In an assay designed to detect antibodies to EBV viral capsid antigens, 41% of dogs were positive. Dogs with cancers, including lymphoma, were more frequently positive than controls, but no particular association with B-cell lymphoma was noted. EBV-specific RNA and DNA sequences were not detected in lymphoma tissue by in situ hybridisation or PCR and herpesvirus genomes were not detected using multiple degenerate PCR assays with the ability to detect novel herpesviruses. We therefore found no evidence that herpesviruses are directly involved in common types of canine lymphoma although cannot exclude the presence of an EBV-like virus in the canine population.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Morris, Professor Joanna and Waugh, Ms Elspeth and Gallagher, Dr Alice and McAulay, Dr Karen
Authors: Waugh, E. M., Gallagher, A., McAulay, K., Henriques, J., Alves, M., Bell, A. J., Morris, J. S., and Jarrett, R. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Journal of General Virology
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
500192BBSRC Doctoral Training Grant 2009-15Massimo PalmariniBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016786/1MVLS III - CENTRE FOR VIRUS RESEARCH
500193BBSRC Doctoral Training Grant 2009-15Massimo PalmariniBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016786/1MVLS III - CENTRE FOR VIRUS RESEARCH