Cell migration within confined sandwich-like nanoenvironments

Ballester-Beltrán, J., Lebourg, M., Rico, P. and Salmeron-Sanchez, M. (2015) Cell migration within confined sandwich-like nanoenvironments. Nanomedicine, 10(5), pp. 815-828. (doi:10.2217/nnm.14.217) (PMID:25816882)

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Abstract

Aim: We introduced sandwich-like cultures to provide cell migration studies with 4 representative nano-bio-environments where both ventral and dorsal cell receptors are activated.

Methods: We have investigated different nano-environmental conditions by changing the protein coating (fibronectin, vitronectin) and/or materials (using polymers that adsorb proteins in qualitatively different conformations) of this sandwich system to show their specific role in cell migration.

Results: Here we show that cell migration within sandwich cultures greatly differs from 2D cultures and shares some similarities with migration within 3D environments. Beyond differences in cell morphology and migration, dorsal stimulation promotes cell remodeling of the ECM over simple ventral 12 receptor activation in traditional 2D cultures.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel
Authors: Ballester-Beltrán, J., Lebourg, M., Rico, P., and Salmeron-Sanchez, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Nanomedicine
Publisher:Future Medicine Ltd.
ISSN:1743-5889
ISSN (Online):1748-6963
Copyright Holders:Copyright © 2015 Future Medicine Ltd.
First Published:First published in Nanomedicine 10(5):815-828
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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