The assessment of the HO· scavenging action of therapeutic agents

Russell, J., Ness, J., Chopra, M., McMurray, J. and Smith, W.E. (1994) The assessment of the HO· scavenging action of therapeutic agents. Journal of Pharmaceutical and Biomedical Analysis, 12(7), pp. 863-866. (doi:10.1016/0731-7085(94)e0022-s) (PMID:7981313)

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Abstract

A new method is reported for the assessment of the HO· scavenging action of therapeutic agents. It is based on the photolysis of zinc oxide and has a detection limit of 3.3%. The scavenging order of the compounds tested was penicillamine > rentiapril > ascorbic acid > cysteine > glutathione > thiomalic acid > N-acetylcysteine > myocrysin > methionine. None were as effective as DMSO. argued that these compounds can have an in vivo protective effect where HO· is produced from oxidant producing cells, thus limiting radical induced damage.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: Russell, J., Ness, J., Chopra, M., McMurray, J., and Smith, W.E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Pharmaceutical and Biomedical Analysis
Publisher:Elsevier B.V.
ISSN:0731-7085
ISSN (Online):1873-264X

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