Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans

McMurray, J. , McFarlane, L., Coutie, W., Balfour, D. and Struthers, A. (1989) Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans. Journal of Cardiovascular Pharmacology, 14(2), pp. 326-330. (doi:10.1097/00005344-198908000-00021) (PMID:2476609)

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Abstract

The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to -230% of basal levels (p < 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to -130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: McMurray, J., McFarlane, L., Coutie, W., Balfour, D., and Struthers, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Cardiovascular Pharmacology
Publisher:Lippincott Williams & Wilkins
ISSN:0160-2446
ISSN (Online):1533-4023

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