Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction. Journal of Cardiovascular Pharmacology, 31(Sup 1), S290-S293. (doi: 10.1097/00005344-199800001-00081) (PMID:9595462)
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Abstract
lasma levels of immunoreactive endothelin-1 (ET-1) are elevated in chronic heart failure(CHF) and have been reported to correlate closely with pulmonary hemodynamic measurements. We investigated the effects of exogenous ET-1 on the pulmonary vasculature in patients with left ventricular systolic dysfunction (LVD), with or without overt heart failure. ET-1 was infused at 1, 5, and 15 pmol/min into a distal pulmonary artery of 10 patients with LVD. Hemodynamics were measured by a thermodilution catheter and arterial line. Intravascular Doppler and local pulmonary angiography were used to assess local pulmonary blood flow in the first four patients. Systemic hemodynamic changes occurred with ET-1 infusion in a dose-dependent fashion. Mean arterial pressure (100 ± 8-107± 11 mm Hg; p < 0.01) and systemic vascular resistance (1,699± 375-2,033 ± 427 dynes/s/cm-5; p < 0.001) rose, whereas the cardiac index fell from 2.43 ± 0.53 to 2.20 ± 0.491/min/m2(p < 0.002). However, mean pulmonary artery pressure (21 ± 7 mm Hg) and pulmonary vascular resistance (151 ± 43-147 ± 43 dynes/s/cm-5) did not change. Exogenous ET-1, when infused into patients with LVD, causes systemic but not pulmonary vasoconstriction.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | MacLean, Professor Margaret and Dargie, Professor Henry and McMurray, Professor John |
Authors: | Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V., and Dargie, H. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Cardiovascular Pharmacology |
Publisher: | Lippincott Williams & Wilkins |
ISSN: | 0160-2446 |
ISSN (Online): | 1533-4023 |
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