Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction

Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V. and Dargie, H. J. (1998) Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction. Journal of Cardiovascular Pharmacology, 31(Sup 1), S290-S293. (doi: 10.1097/00005344-199800001-00081) (PMID:9595462)

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Abstract

lasma levels of immunoreactive endothelin-1 (ET-1) are elevated in chronic heart failure(CHF) and have been reported to correlate closely with pulmonary hemodynamic measurements. We investigated the effects of exogenous ET-1 on the pulmonary vasculature in patients with left ventricular systolic dysfunction (LVD), with or without overt heart failure. ET-1 was infused at 1, 5, and 15 pmol/min into a distal pulmonary artery of 10 patients with LVD. Hemodynamics were measured by a thermodilution catheter and arterial line. Intravascular Doppler and local pulmonary angiography were used to assess local pulmonary blood flow in the first four patients. Systemic hemodynamic changes occurred with ET-1 infusion in a dose-dependent fashion. Mean arterial pressure (100 ± 8-107± 11 mm Hg; p < 0.01) and systemic vascular resistance (1,699± 375-2,033 ± 427 dynes/s/cm-5; p < 0.001) rose, whereas the cardiac index fell from 2.43 ± 0.53 to 2.20 ± 0.491/min/m2(p < 0.002). However, mean pulmonary artery pressure (21 ± 7 mm Hg) and pulmonary vascular resistance (151 ± 43-147 ± 43 dynes/s/cm-5) did not change. Exogenous ET-1, when infused into patients with LVD, causes systemic but not pulmonary vasoconstriction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Dargie, Professor Henry and McMurray, Professor John
Authors: Cowburn, P. J., Cleland, J. G.F., McArthur, J. D., MacLean, M. R., McMurray, J. J.V., and Dargie, H. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Cardiovascular Pharmacology
Publisher:Lippincott Williams & Wilkins
ISSN:0160-2446
ISSN (Online):1533-4023

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