Health related quality of life in I-PRESERVE trial

Carson, P. et al. (2008) Health related quality of life in I-PRESERVE trial. Journal of Cardiac Failure, 14(6), S73. (doi:10.1016/j.cardfail.2008.06.200)

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Purpose: Little is known about health-related quality of life (QHRQL) in patients with HF and preserved EF (HF-PEF). We studied the impact of HF-PEF on HRQL (and the determinants of HRQL in patients with HF-PEF) in the Irbesartan in Heart Failure with Preserved Systolic Function trial.

Methods: At baseline, 3,622 patients with an EF ≥ 45% from 25 countries completed the extensively studied and validated Minnesota Living with Heart Failure questionnaire (MLwHF), a 21 item disease-specific instrument. A summary score of 0–105 is possible, with a higher score reflecting worse HRQL. In order to examine relationships between pathophysiology, symptoms/signs and HRQL, NYHA class (see table), peripheral oedema (see table), EF (quartiles) and plasma concentration of NT proBNP (quartiles) were divided into 4 categories.

Results: Mean age was 72 (range 53–95) years and 61% were female. Mean MLwHF score was 42.4 (SD 20.7). There was no relationship between EF or NT proBNP and HRQL whereas NYHA class and oedema were strongly correlated with HROL.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: Carson, P., McMurray, J., Komajda, M., Zile, M., Ptaszynska, A., Jackson, J., McKelvie, R., Rector, T., Grinspan, J., Staiger, C., and Massie, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Cardiac Failure
Publisher:Elsevier Inc.
ISSN (Online):1532-8414

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