Mackley, E. C. et al. (2015) CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications, 6, (doi: 10.1038/ncomms6862) (PMID:25575242) (PMCID:PMC4354100)
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Abstract
Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Milling, Professor Simon and Cerovic, Dr Vuk and Houston, Miss Stephanie and Maizels, Professor Rick |
| Authors: | Mackley, E. C., Houston, S., Marriott, C. L., Halford, E. E., Lucas, B., Cerovic, V., Filbey, K. J., Maizels, R. M., Hepworth, M. R., Sonnenberg, G. F., Milling, S., and Withers, D. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Communications |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2015 Macmillan Publishers Limited |
| First Published: | First published in Nature Communications 6:5862 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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