Structure and function of the UV-B photoreceptor UVR8

Jenkins, G. I. (2014) Structure and function of the UV-B photoreceptor UVR8. Current Opinion in Structural Biology, 29, pp. 52-57. (doi:10.1016/j.sbi.2014.09.004)

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Abstract

UVR8 is a UV-B photoreceptor that employs specific tryptophans in its primary sequence as chromophores in photoreception. UV-B absorption causes dissociation of the dimeric photoreceptor by neutralizing interactions between monomers. The monomeric form initiates signalling through interaction with the COP1 protein, leading to transcriptional responses. This article discusses the structural basis of UVR8 function, highlighting recent research on the mechanism of photoreception and on interactions with other proteins involved in signalling and regulation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jenkins, Professor Gareth
Authors: Jenkins, G. I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Opinion in Structural Biology
Publisher:Elsevier
ISSN:0959-440X
ISSN (Online):1879-033X

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