Two cases of possible transmitted drug resistant HIV virus: likely HIV superinfection and unmasking of pre-existing resistance

Martin, F., Lee, J., Thomson, E. , Tarrant, N., Hale, A. and Lacey, C. J. (2016) Two cases of possible transmitted drug resistant HIV virus: likely HIV superinfection and unmasking of pre-existing resistance. International Journal of STD and AIDS, 27(1), pp. 66-69. (doi:10.1177/0956462415571671) (PMID:25663247) (PMCID:PMC4674743)

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Abstract

In the UK, patients undergo HIV viral load and genotype testing before they are prescribed highly active antiretroviral therapy. The genotype test guides clinicians in prescribing highly active antiretroviral therapy with maximum efficacy against the patient's specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted diseases. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Dr Emma
Authors: Martin, F., Lee, J., Thomson, E., Tarrant, N., Hale, A., and Lacey, C. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of STD and AIDS
Journal Abbr.:Int. J. STD AIDS
Publisher:Sage Publications
ISSN:0956-4624
ISSN (Online):1758-1052
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in International Journal of STD and AIDS 27(1): 66-69
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
645101T-cell mediated evolution of hepatitis C virus during acute infectionEmma ThomsonWellcome Trust (WELLCOME)102789/Z/13/ZMVLS III - CENTRE FOR VIRUS RESEARCH